Concepedia

Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism

Ee Phie Tan, Steven R. McGreal, Stefan Graw, Robert Tessman, Scott J. Koppel, Pramod Dhakal, Zhen Zhang, Miranda Machacek, Natasha E. Zachara, Devin C. Koestler,

Journal of Biological Chemistry · 2017 · 108 citations · 48 references

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Abstract

GlcNAcylation coupled with increased OGA expression reprograms energy metabolism, a finding that has potential implications for the etiology, development, and management of metabolic diseases.

References

48

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

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Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

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Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

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The Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte Ribosomes

Tom G. Obrig, William Culp, Wallace L. McKeehan · Journal of Biological Chemistry · 1971 · 518 citations · Full text

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