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Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama‐Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa,

Bioorganic & Medicinal Chemistry Letters · 2017 · 14 citations · 13 references

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The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

Luı́s de Lecea, Thomas S. Kilduff, Christelle Peyron et al. · Proceedings of the National Academy of Sciences · 1998 · 3.9K citations

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Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine

Minoru Narita, Yasuyuki Nagumo, Seiko Hashimoto et al. · Journal of Neuroscience · 2006 · 517 citations · Full text

, , +17

Orexin (Hypocretin) Neurons Contain Dynorphin

Thomas C. Chou, Charlotte E. Lee, Jing Lü et al. · Journal of Neuroscience · 2001 · 428 citations · Full text

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Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists

Alessandro Gozzi, Giuliano Turrini, Laura Piccoli et al. · PLoS ONE · 2011 · 102 citations · Full text

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Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration

Hiroshi Nagase, Toru Nemoto, Ayaka Matsubara et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 78 citations · Full text

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