Sayaka Ohrui

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Hiroshi Nagase, Naoshi Yamamoto, Masahiro Yata et al. · Journal of Medicinal Chemistry · 2017 · 36 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 14 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Sayaka Ohrui, Naoshi Yamamoto, Tsuyoshi Saitoh et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 14 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada et al. · Bioorganic & Medicinal Chemistry · 2019 · 10 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

A Photoredox/Sulfide Dual Catalysis System That Uses Sulfide Radical Cations to Promote Alkene Chlorotrifluoromethylation

Kakeru Matsukuma, Masanori Tayu, Y. Yashiro et al. · Chemical and Pharmaceutical Bulletin · 2023 · 10 citations · Full text

Natural Sciences, Chemistry, Catalysis +7