Concepedia

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

Danny Ben‐Avraham, Diddahally R. Govindaraju, Temuri Budagov, Delphine Fradin, Peter Durda, Bing Liu, Sandy Ott, Danielle Gutman, Lital Sharvit, Robert C. Kaplan,

Science Advances · 2017 · 57 citations · 39 references

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Concepts

Abstract

variant is a common genetic polymorphism that modulates GH responsiveness throughout the life span and positively affects male longevity.

References

39

The cardiovascular health study: Design and rationale

Linda P. Fried, Nemat O. Borhani, Paul Enright et al. · Annals of Epidemiology · 1991 · 3.7K citations

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PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis

Jeffrey R. O'Connell, Daniel E. Weeks · The American Journal of Human Genetics · 1998 · 2.1K citations · Full text

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Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

Jaime Guevara‐Aguirre, Priya Balasubramanian, Marco Guevara‐Aguirre et al. · Science Translational Medicine · 2011 · 737 citations · Full text

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Functionally significant insulin-like growth factor I receptor mutations in centenarians

Yousin Suh, Gil Atzmon, Mi-Ook Cho et al. · Proceedings of the National Academy of Sciences · 2008 · 696 citations · Full text

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Abnormality of Gait as a Predictor of Non-Alzheimer's Dementia

Joe Verghese, Richard B. Lipton, Charles B. Hall et al. · New England Journal of Medicine · 2002 · 689 citations · Full text

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