Concepedia

Deletion of interleukin 1 receptor-associated kinase 1 (Irak1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle

Xiao‐Jian Sun, Soohyun Park Kim, Dongming Zhang, Helen Sun, Qi Cao, Xin Lü, Zhekang Ying, Liwu Li, Robert R. Henry, Theodore P. Ciaraldi,

Journal of Biological Chemistry · 2017 · 31 citations · 72 references

DOIFull text

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Concepts

Abstract

deletion improved muscle insulin sensitivity, with the effect being most apparent in LFD mice.

References

72

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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, , +14