Cell Reports · 2017 · 196 citations · 42 references
Life SciencesImmunologyMolecular BiologyAntibody EngineeringMolecular VirologyVirologyAntibody CharacterizationAntibody-antigen RecognitionAntiviral ImmunityGlycan AnalysisGlycan StructureGlycan-protein InteractionsAntibodiesGlycan-mediated Immune RecognitionGlycosylated AntigensHiv Envelope Glycoprotein AntigensNeutralizationNeutralization PotentialSurface AreaViral Glycan Shielding
) proportional to the exponential of the protein-surface area accessible to antibody. Based on these high titers and exponential relationship, we propose site-selective deglycosylated trimers as priming immunogens to increase the frequency of site-targeting antibodies.
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Antibody neutralization and escape by HIV-1
Xiping Wei, Julie M. Decker, Shuyi Wang et al. · Nature · 2003 · 2.4K citations
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
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