Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold

Discovery of Novel, Potent, and Selective Small-Molecule CCR5 Antagonists as Anti-HIV-1 Agents:  Synthesis and Biological Evaluation of Anilide Derivatives with a Quaternary Ammonium Moiety

Mitsuru Shiraishi, Yoshio Aramaki, Masaki Seto et al. · Journal of Medicinal Chemistry · 2000 · 185 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Loss of CCR2 Expression and Functional Response to Monocyte Chemotactic Protein (MCP-1) During the Differentiation of Human Monocytes: Role of Secreted MCP-1 in the Regulation of the Chemotactic Response

Laura Fantuzzi, Paola Borghi, V. Ciolli et al. · Blood · 1999 · 174 citations

Life Sciences, Cell Biology, Immunology +17

Highly Potent and Orally Active CCR5 Antagonists as Anti-HIV-1 Agents:  Synthesis and Biological Activities of 1-Benzazocine Derivatives Containing a Sulfoxide Moiety

Masaki Seto, Katsuji Aikawa, Naoki Miyamoto et al. · Journal of Medicinal Chemistry · 2006 · 89 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Multiple Binding Sites for Small-Molecule Antagonists at the CC Chemokine Receptor 2

Annelien J.M. Zweemer, Indira Nederpelt, Hilde Vrieling et al. · Molecular Pharmacology · 2013 · 68 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Structural Insights from Binding Poses of CCR2 and CCR5 with Clinically Important Antagonists: A Combined In Silico Study

Gugan Kothandan, Changdev G. Gadhe, Seung Joo Cho · PLoS ONE · 2012 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17