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Identification of 3-substituted-6-(1-(1 H -[1,2,3]triazolo[4,5- b ]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural SciencesRational Drug DesignQuinoline DerivativesAnti-cancer AgentDrug DevelopmentPharmacologyPharmaceutical ChemistryDrug Discovery