20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (G _q ) to Affect Vascular Function and Trigger Hypertension

Abstract

This is the first report to identify a GPCR target for an eicosanoid of this class. The discovery of 20-HETE-GPR75 pairing presented here provides the molecular basis for the signaling and pathophysiological functions mediated by 20-HETE in hypertension and cardiovascular diseases.