Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity

Parsa Akbari, Ankit Gilani, Olukayode Sosina, +57

Science

Substrate binding site flexibility of the small heat shock protein molecular chaperones

Nomalie Jaya, Víctor García, Elizabeth Vierling

Proceedings of the National Academy of Sciences

Protein AssemblyDodecameric Pshsp18.1Molecular BiologyProtein RefoldingProtein Folding +14

20-HETE Signals Through G-Protein–Coupled Receptor GPR75 (G _q ) to Affect Vascular Function and Trigger Hypertension

Víctor García, Ankit Gilani, Brian Shkolnik, +11

Circulation Research

Induction of Angiotensin-Converting Enzyme and Activation of the Renin–Angiotensin System Contribute to 20-Hydroxyeicosatetraenoic Acid–Mediated Endothelial Dysfunction

Jennifer Cheng, Víctor García, Yan Ding, +5

Arteriosclerosis Thrombosis and Vascular Biology

20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding

Víctor García, Brian Shkolnik, Laura Milhau, +2

Journal of Pharmacology and Experimental Therapeutics

Androgen-Sensitive Hypertension Associates with Upregulated Vascular CYP4A12–20-HETE Synthase

Cheng–Chia Wu, Shaojun Mei, Jennifer Cheng, +9

Journal of the American Society of Nephrology

HypertensionDoxycycline-sensitive PromoterFemale Reproductive FunctionAndrogen-sensitive HypertensionReproductive Endocrinology +20

Hypertension Is a Major Contributor to 20-Hydroxyeicosatetraenoic Acid–Mediated Kidney Injury in Diabetic Nephropathy

Mahesha Gangadhariah, James M. Luther, Víctor García, +11

Journal of the American Society of Nephrology

Hypertension20-Hete AntagonistRenal PathologyRenal InflammationOxidative Stress +21

Uncovering the signalling, structure and function of the 20‐HETE‐GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75

Jonathan V. Pascale, Eon Joo Park, Adeniyi Michael Adebesin, +3

British Journal of Pharmacology

High-fat diet-induced obesity and insulin resistance in CYP4a14^−/− mice is mediated by 20-HETE

Ankit Gilani, Varunkumar Pandey, Víctor García, +9

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2

Jennifer Cheng, Matthew L. Edin, Samantha L. Hoopes, +14

The FASEB Journal

Nadph OxidaseLipid PeroxidationRedox BiologyOxidative StressInflammation +22