Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents

Molecular Evolution of the Histone Deacetylase Family: Functional Implications of Phylogenetic Analysis

IvanV Gregoretti, Yunmi Lee, Holly V. Goodson · Journal of Molecular Biology · 2004 · 1.5K citations

Life Sciences, Genetics, Molecular Biology +14

Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

Wilko Weichert, A.-E. Roske, Volker Gekeler et al. · British Journal of Cancer · 2008 · 479 citations · Full text

Medicine, Molecular Biology, Oncology +17

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou et al. · Molecular Cancer Therapeutics · 2008 · 336 citations · Full text

Medicine, Oncology, Pharmacology +13

Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.

Jane A. Plumb, Paul W. Finn, Robert J. Williams et al. · PubMed · 2003 · 313 citations

Medicine, Oncology, Pharmacology +15

Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

Teppei Yamaguchi, Fabien Cubizolles, Yu Zhang et al. · Genes & Development · 2010 · 294 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17