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NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B <sub>4</sub> Synthesis

DOIFull Paper Access

150

Citations

34

References

2017

Year

Seonmin Lee, Kiichi Nakahira, Jesmond Dalli, Ilias Ι. Siempos, Paul C. Norris, Romain A. Colas, Jong‐Seok Moon, Masakazu Shinohara, Shu Hisata, Judie A. Howrylak,
American Journal of Respiratory and Critical Care Medicine

Abstract

Genetic deficiency of NLRP3 promoted resolution of inflammation in polymicrobial sepsis by relieving caspase-7-dependent repression of LXB<sub>4</sub> biosynthesis, and increased survival potentially via LXB<sub>4</sub> production and inhibition of proinflammatory cytokines.

References

YearCitations

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