The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Francine E. Garrett-Bakelman, Manjula Darshi, Stefan J. Green, +79

Science

GeneticsAverage Telomere LengthGenetic EpidemiologyGenetic FoundationEpigenetics +15

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

Scott W. Wong, Myung‐Ja Kwon, Augustine M.K. Choi, +3

Journal of Biological Chemistry

Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury

Tamás Dolinay, Young Sam Kim, Judie A. Howrylak, +17

American Journal of Respiratory and Critical Care Medicine

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

Kiichi Nakahira, Sunyoung Kyung, Angela J. Rogers, +21

PLoS Medicine

RETRACTED: mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

Jong-Seok Moon, Shu Hisata, Mi Ae Park, +4

Cell Reports

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

Kiichi Nakahira, Shu Hisata, Augustine M.K. Choi

Antioxidants and Redox Signaling

RETRACTED ARTICLE: NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

Jong‐Seok Moon, Kiichi Nakahira, Kuei‐Pin Chung, +8

Nature Medicine

InflammationAnti-inflammatoryImmunologyChronic InflammationCell Death +8

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

Jong-Seok Moon, Seonmin Lee, Mi‐Ae Park, +9

Journal of Clinical Investigation

Inflammatory Lung DiseaseLung InflammationInnate Immune SystemImmunologyImmune Regulation +20

BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension

Isabel Diebold, Jan K. Hennigs, Kazuya Miyagawa, +13

Cell Metabolism

Pulmonary Arterial HypertensionMolecular PhysiologyMitochondrial FunctionPhysiologyVascular Biology +7

Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis

Divya Bhatia, Kuei‐Pin Chung, Kiichi Nakahira, +7

JCI Insight