Concepedia

Is estrogen exposure a protective factor for pancreatic neuroendocrine tumours in female patients with multiple endocrine neoplasia syndrome type 1?

Wei Qiu, Ioannis Christakis, Ashley A. Stewart, Danica M. Vodopivec, Angelica M. Silva, Huiqin Chen, Terri L. Woodard, Daniel M. Halperin, Jeffrey E. Lee, James C. Yao,

Clinical Endocrinology · 2017 · 17 citations · 23 references

DOI

Abstract

In female patients with MEN1, estrogen exposure may inhibit PNET growth. A demonstrable protective effect against PNET tumourigenesis, tumour growth and survival of patients with these tumours may require a larger cohort.

References

23

Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support

Paul A. Harris, Robert Taylor, Robert J. Thielke et al. · Journal of Biomedical Informatics · 2008 · 48.8K citations · Full text

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Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27 <i> <sup>Kip1</sup> </i> and p18 <i> <sup>INK4c</sup> </i>

Satyajit Karnik, Christina M. Hughes, Xueying Gu et al. · Proceedings of the National Academy of Sciences · 2005 · 388 citations · Full text

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Menin Controls Growth of Pancreatic ß-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus

Satyajit Karnik, Hainan Chen, Graeme W. McLean et al. · Science · 2007 · 346 citations

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Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients

Pierre Goudet, Arnaud Murat, Christine Binquet et al. · World Journal of Surgery · 2009 · 333 citations

Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion

Nicholas V. Costrini, R K Kalkhoff · Journal of Clinical Investigation · 1971 · 285 citations · Full text

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