A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Nicole Almanzar, Jane Antony, Ankit S. Baghel, +131

Nature

Cell LineageDevelopmental BiologySingle-cell Transcriptomic AtlasSingle Cell SequencingMedicine +6

Ageing hallmarks exhibit organ-specific temporal signatures

Nicholas Schaum, Benoit Lehallier, Oliver Hãhn, +158

Nature

Signal TransductionAgingDevelopmental BiologyLongevityCellular Senescence +5

Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function

Jeremy J. Heit, Åsa Apelqvist, Xueying Gu, +4

Nature

Signal TransductionSignaling PathwayPancreatic CancerCellular BiochemistryMedicine +4

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27 <i> ^Kip1 </i> and p18 <i> ^INK4c </i>

Satyajit Karnik, Christina M. Hughes, Xueying Gu, +5

Proceedings of the National Academy of Sciences

Histone ModificationsEpigenetic ChangeCancer BiologyEpigeneticsInsulin Signaling +21

Polycomb protein Ezh2 regulates pancreatic β-cell <i>Ink4a/Arf</i> expression and regeneration in diabetes mellitus

Hainan Chen, Xueying Gu, I-hsin Su, +4

Genes & Development

Molecular RegulationEpigenetic ChangeEpigeneticsBeta CellsTranscriptional Regulation +16

Menin Controls Growth of Pancreatic ß-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus

Satyajit Karnik, Hainan Chen, Graeme W. McLean, +6

Science

Developmental BiologySignal TransductionMenin Controls GrowthEndocrine MechanismMedicine +13

Wnt signaling regulates pancreatic β cell proliferation

Ingrid C. Rulifson, Satyajit Karnik, Patrick W. Heiser, +7

Proceedings of the National Academy of Sciences

Beta Cell ProliferationInsulin SignalingMolecular PhysiologySignal TransductionTissue Development +13

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

Hainan Chen, Xueying Gu, Yinghua Liu, +6

Nature

Pancreatic CancerControls Age-dependent ProliferationMedicineCell BiologyCell Signaling

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

H. Efsun Arda, Lingyu Li, Jennifer Tsai, +16

Cell Metabolism

Developmental BiologyMolecular PhysiologySignal TransductionLongevityCellular Senescence +4

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx

Harini Chakravarthy, Xueying Gu, Martin Enge, +14

Cell Metabolism

Both Dnmt1Pancreatic Islet BiologyImmunologyPancreas TransplantationMedicine +4