TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Itaru Urakawa, Yuji Yamazaki, Takashi Shimada et al. · Nature · 2006 · 1.8K citations

Life Sciences, Genetics, Molecular Biology +10

Origin and function of myofibroblasts in kidney fibrosis

Valerie S. LeBleu, Gangadhar Taduri, Joyce T. O’Connell et al. · Nature Medicine · 2013 · 1.2K citations · Full text

Medicine, Cell Biology, Nephrology +12

Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦

Masaya Yamamoto, Jeremy D. Clark, Johanne V. Pastor et al. · Journal of Biological Chemistry · 2005 · 727 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Methylation determines fibroblast activation and fibrogenesis in the kidney

Wibke Bechtel‐Walz, Scott McGoohan, Elisabeth M. Zeisberg et al. · Nature Medicine · 2010 · 624 citations · Full text

Medicine, Molecular Biology, Nephrology +12

TGF-β/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29

Wei Qin, Arthur C.K. Chung, Xiao Ru Huang et al. · Journal of the American Society of Nephrology · 2011 · 557 citations · Full text

Medicine, Molecular Medicine, Nephrology +17