Concepedia

Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor

Meredith A. Rowe, Lindsey Harper, Margaret A. McNulty, Anthony G. Lau, Cathy S. Carlson, Lin Leng, Richard Bucala, Richard A. Miller, Richard F. Loeser

Arthritis & Rheumatology · 2016 · 70 citations · 39 references

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Open access

Abstract

These results demonstrate a differential mechanism in the pathogenesis of naturally occurring age-related OA compared to injury-induced OA. The inhibition of MIF may represent a novel therapeutic target in the reduction of the severity of age-related OA.

References

39

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

Jürgen Bernhagen, Regina M. Krohn, Hongqi Lue et al. · Nature Medicine · 2007 · 1.2K citations

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MIF Signal Transduction Initiated by Binding to CD74

Lin Leng, Christine N. Metz, Yan Fang et al. · The Journal of Experimental Medicine · 2003 · 1.1K citations · Full text

The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor.

Thierry Calandra, Jürgen Bernhagen, Robert A. Mitchell et al. · The Journal of Experimental Medicine · 1994 · 986 citations · Full text

Synovial tissue inflammation in early and late osteoarthritis

M J Benito · Annals of the Rheumatic Diseases · 2005 · 984 citations · Full text

Morphometric Analysis of Human Bone Biopsies: A Quantitative Structural Comparison of Histological Sections and Micro-Computed Tomography

Ralph Müller, H Van Campenhout, Bart Van Damme et al. · Bone · 1998 · 651 citations

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