F1000Research · 2017 · 124 citations · 31 references
Life SciencesCell BiologyMolecular BiologyCell SignalingMolecular Cell BiologySignal TransductionCancer Cell SignalingCell Signaling NetworksCross-talk Between Signaling PathwaysProtein Kinase CascadesSignal Transduction ComplexesSignal Transduction PathwaysCell Signaling CrosstalkCrosstalkExtracellular Signal-regulated Kinase PathwayExtracellular Signal-regulated Kinase SignalingGlycogen Synthase Kinase 3 RegulationGlycogen Synthase Kinase 3 SignalingIntegration Of Kinase CascadesSignal Integration In Kinase Networks
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed protein kinase that sits at the nexus of multiple signaling pathways. Its deep integration into cellular control circuits is consummate to its implication in diseases ranging from mood disorders to diabetes to neurodegenerative diseases and cancers. The selectivity and insulation of such a promiscuous kinase from unwanted crosstalk between pathways, while orchestrating a multifaceted response to cellular stimuli, offer key insights into more general mechanisms of cell regulation. Here, we review recent advances that have contributed to the understanding of GSK-3 and its role in driving appreciation of intracellular signal coordination.
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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
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Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation
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