Valproic acid downregulates heme oxygenase-1 independently of Nrf2 by increasing ubiquitination and proteasomal degradation

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 4K citations

Life Sciences, Biochemistry, Molecular Biology +14

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Martin Göttlicher · The EMBO Journal · 2001 · 1.9K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Tetsuro Ishii, Ken Itoh, Satoru Takahashi et al. · Journal of Biological Chemistry · 2000 · 1.5K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

Glenn F. Vile, Sharmila Basu‐Modak, C. Waltner et al. · Proceedings of the National Academy of Sciences · 1994 · 514 citations

Life Sciences, Biochemistry, Dermatology +17

Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants

Saravanakumar Dhakshinamoorthy, Abhinav K. Jain, David A. Bloom et al. · Journal of Biological Chemistry · 2005 · 405 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16