Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in <i> Ldlr ^−/− </i> Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid

Abstract

Bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a mouse model of metabolic dysregulation.