Concepedia

Neutrophils acquire the capacity for antigen presentation to memory CD4+ T cells in vitro and ex vivo

Maria Vono, Ang Lin, Anna Norrby‐Teglund, Richard A. Koup, Karin Loré

Blood · 2017 · 307 citations · 41 references

DOI

Concepts

Abstract

T cells ex vivo. Altogether, the data demonstrate that neutrophils can adapt a function as APCs and, in combination with their abundance in the immune system, may have a significant role in regulating antigen-specific T-cell responses.

References

41

Neutrophil Extracellular Traps Kill Bacteria

Volker Brinkmann, Ulrike Reichard, Christian Goosmann et al. · Science · 2004 · 10.1K citations

, , +17

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Zvi G. Fridlender, Jing Sun, Samuel Kim et al. · Cancer Cell · 2009 · 3.3K citations · Full text

, , +12

Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate

Lélia Delamarre, Margit Pack, Henry Chang et al. · Science · 2005 · 749 citations

, , +17

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Irene Puga, Montserrat Cols, Carolina Barra et al. · Nature Immunology · 2011 · 721 citations

, , +14

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity

Sandra Morel, Arnaud M. Didierlaurent, Patricia Bourguignon et al. · Vaccine · 2011 · 472 citations

, , +16