TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension

Kirk B. Lane, Rajiv D. Machado, Michael W. Pauciulo et al. · Nature Genetics · 2000 · 1.5K citations

Hypertension, Pulmonary Arterial Hypertension, Tgf-β Receptor +11

Familial Primary Pulmonary Hypertension (Gene PPH1) Is Caused by Mutations in the Bone Morphogenetic Protein Receptor–II Gene

Zemin Deng, Jane H. Morse, Susan L. Slager et al. · The American Journal of Human Genetics · 2000 · 1.2K citations · Full text

Hypertension, Gene Pph1, Developmental Biology +11

A Novel Proteolytic Cleavage Involved in Notch Signaling

Christel Brou, Frédérique Logeat, Neetu Gupta et al. · Molecular Cell · 2000 · 1.1K citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +6

Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension.

Rubin M. Tuder, Bertron Μ. Groves, David B. Badesch et al. · PubMed · 1994 · 802 citations · Full text

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

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