Concepedia

Induction of potent apoptosis by an anti-CD20 aptamer via the crosslink of membrane CD20 on non-Hodgkin's lymphoma cells

Cong Wu, Wei Wan, Ji Zhu, Hai Jin, Tiejun Zhao, Huafei Li

RSC Advances · 2017 · 12 citations · 27 references

DOIFull text

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Concepts

Abstract

An anti-CD20 DNA aptamer was successfully generated by cell-SELEX, the crosslink of which can induce potent apoptosis in target cells.

References

27

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell · 1997 · 7.2K citations · Full text

, , +12

Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics

Sumedha D. Jayasena · Clinical Chemistry · 1999 · 2.1K citations · Full text

, , +18

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

Christoph T. Ellebrecht, Vijay Bhoj, Arben Nace et al. · Science · 2016 · 670 citations · Full text

, , +17

Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas

Jessica L. Teeling · Blood · 2004 · 623 citations · Full text

The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20

Jessica L. Teeling, Wendy J.M. Mackus, Luus Wiegman et al. · The Journal of Immunology · 2006 · 599 citations