Obesity induces pro-inflammatory B cells and impairs B cell function in old mice

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

Daniel A. Winer, Shawn Winer, Lei Shen et al. · Nature Medicine · 2011 · 1K citations

Insulin Resistance, Autoimmune Disease, T-regulatory Cell +11

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

Mario Kratz, Brittney R. Coats, Katherine B. Hisert et al. · Cell Metabolism · 2014 · 781 citations · Full text

Obesity, Metabolic Syndrome, Inflammation +15

Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

Anatoly V. Rubtsov, Kira Rubtsova, Aryeh Fischer et al. · Blood · 2011 · 775 citations · Full text

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

I. Murano, Giorgio Barbatelli, V. Parisani et al. · Journal of Lipid Research · 2008 · 696 citations · Full text

Metabolic Disorder, Immunology, Pathology +20

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Yi Hao, Patrick J. O’Neill, Martin S. Naradikian et al. · Blood · 2011 · 588 citations