Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

Anatoly V. Rubtsov, Kira Rubtsova, Aryeh Fischer, +4

Blood

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

Kira Rubtsova, Anatoly V. Rubtsov, Linda F. van Dyk, +2

Proceedings of the National Academy of Sciences

Efficient Antibody IsotypeAdaptive Immune SystemT-regulatory CellImmunologyImmune Regulation +24

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

Kira Rubtsova, Anatoly V. Rubtsov, Joshua M. Thurman, +3

Journal of Clinical Investigation

ImmunogeneticsAutoimmune DiseaseSystemic Lupus ErythematosusSystemic Lupus Erythematosus TreatmentLupus +13

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

Anatoly V. Rubtsov, Kira Rubtsova, John W. Kappler, +3

The Journal of Immunology

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice

Anatoly V. Rubtsov, Kira Rubtsova, John W. Kappler, +1

Immunologic Research

InflammationAutoimmune DiseaseAllergyAutoantibody ProductionImmune Cell Development +7

TLR Agonists Promote Marginal Zone B Cell Activation and Facilitate T-Dependent IgM Responses

Anatoly V. Rubtsov, Cristina L. Swanson, Scott Troy, +3

The Journal of Immunology

Lsc Regulates Marginal-Zone B Cell Migration and Adhesion and Is Required for the IgM T-Dependent Antibody Response

Anatoly V. Rubtsov, Pamela Strauch, Alyssa DiGiacomo, +3

Immunity

Signal TransductionAutoimmune DiseaseCell TraffickingHumoral ResponseImmunology +9

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

Kira Rubtsova, Anatoly V. Rubtsov, Kalani Halemano, +4

PLoS ONE

T Cell ProductionAdaptive Immune SystemImmunodeficienciesImmunologyImmune Regulation +20

Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice

Emilie Fournier, Maria-Gabriela Velez, Katelyn F. Leahy, +4

The Journal of Experimental Medicine

Autoimmune MiceAdaptive Immune SystemHumoral ResponseImmunologyImmune Regulation +24

Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity

Jennifer D. Larson, Joshua M. Thurman, Anatoly V. Rubtsov, +5

Proceedings of the National Academy of Sciences

Murine Gammaherpesvirus 68Viral PathogenesisImmunologyPathologyAutoantibody Levels +21