Dual role of interleukin‐1β in islet amyloid formation and its β‐cell toxicity: <scp>I</scp> mplications for type 2 diabetes and islet transplantation

Abstract

IL-1β plays a dual role by: (1) mediating amyloid-induced Fas upregulation and β-cell apoptosis; (2) inducing impaired proIAPP processing thereby potentiating amyloid formation. Blocking IL-1β may provide a new strategy to preserve β cells in conditions associated with islet amyloid formation.