Sequential Exposure of Bortezomib and Vorinostat is Synergistic in Multiple Myeloma Cells

The problem of synergism and antagonism of combined drugs.

S. Loewe · PubMed · 1953 · 984 citations

Medicine, Pharmacology, Pharmacotherapy +9

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

Michael J. Lee, Albert S. Ye, Alexandra K. Gardino et al. · Cell · 2012 · 697 citations · Full text

Life Sciences, Cell Biology, Oncology +16

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

Teru Hideshima, Constantine S. Mitsiades, Masaharu Akiyama et al. · Blood · 2003 · 569 citations · Full text

Medicine, Oncology, Pharmacology +13

Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors

Xin‐Yan Pei, Yun Dai, Steven Grant · Clinical Cancer Research · 2004 · 381 citations

Medicine, Oncology, Pharmacology +17

Evaluation of Combination Chemotherapy

Liang Zhao, M. Guillaume Wientjes, Jessie L.‐S. Au · Clinical Cancer Research · 2004 · 377 citations

Medicine, Pharmacology, Pharmacotherapy +14