Masaharu Akiyama

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

Keiko Hiyama, Yoshikatsu Hirai, Seishi Kyoizumi et al. · The Journal of Immunology · 1995 · 866 citations

Life Sciences, Cell Biology, Molecular Biology +16

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

Constantine S. Mitsiades, Nicholas Mitsiades, Ciaran J. McMullan et al. · Cancer Cell · 2004 · 611 citations

Medicine, Hematology, Oncology +17

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

Teru Hideshima, Constantine S. Mitsiades, Masaharu Akiyama et al. · Blood · 2003 · 569 citations · Full text

Medicine, Oncology, Pharmacology +13

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications

Constantine S. Mitsiades, Nicholas Mitsiades, Ciaran J. McMullan et al. · Proceedings of the National Academy of Sciences · 2003 · 531 citations · Full text

Medicine, Oncology, Pharmacology +17

Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

Constantine S. Mitsiades, Nicholas Mitsiades, Vassiliki Poulaki et al. · Oncogene · 2002 · 463 citations

Life Sciences, Cell Biology, Oncology +17