Leptin receptor knockout-induced depression-like behaviors and attenuated antidepressant effects of exercise are associated with STAT3/SOCS3 signaling

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

Medicine, Pharmacology, Psychiatry +17

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Hong Chen, Olga Charlat, Louis A. Tartaglia et al. · Cell · 1996 · 2.2K citations · Full text

Life Sciences, Endocrinology, Genetics +11

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Paul Willner, Anthony Towell, D. Sampson et al. · Psychopharmacology · 1987 · 2K citations

Medicine, Behavioral Sciences, Pharmacology +15

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Xiaoqing Zhang, Guo Zhang, Hai Zhang et al. · Cell · 2008 · 1.3K citations · Full text

Life Sciences, Neurobiology, Physiology +16

The stomach is a source of leptin

André Bado, Sandrine Levasseur, Samir Attoub et al. · Nature · 1998 · 1.2K citations

Life Sciences, Endocrinology, Physiology +6