Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Xiaoqing Zhang, Guo Zhang, Hai Zhang, +3

Cell

ObesityMetabolic SyndromeInflammationHypothalamic Ikkβ/nf-κbEnergy Homeostasis +6

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

Baoyang Hu, Jason P. Weick, Junying Yu, +4

Proceedings of the National Academy of Sciences

Variable PotencyAdult Stem CellStem Cell DifferentiationCell DifferentiationCell Specialization +19

Pax6 Is a Human Neuroectoderm Cell Fate Determinant

Xiaoqing Zhang, Cindy Huang, Jing Chen, +12

Cell stem cell

Human CellDevelopmental BiologyEpendymaNeuroanatomyCell Fate Determination +4

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

Xue Jun Li, Xiaoqing Zhang, M. Austin Johnson, +3

Development

Adult Stem CellCell SpecializationSonic HedgehogDirected DifferentiationEpendyma +15

A Nuclear Function of β-Arrestin1 in GPCR Signaling: Regulation of Histone Acetylation and Gene Transcription

Jiuhong Kang, Yufeng Shi, Bin Xiang, +11

Cell

Molecular RegulationMolecular BiologyTranscriptional RegulationSignaling PathwayCell Regulation +15

Human Embryonic Stem Cell-Derived GABA Neurons Correct Locomotion Deficits in Quinolinic Acid-Lesioned Mice

Lixiang Ma, Baoyang Hu, Yan Liu, +6

Cell stem cell

Quinolinic Acid-lesioned MiceDevelopmental BiologyMedicineCerebral OrganoidNeurogenesis +7

Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits

Yan Liu, Jason P. Weick, Huisheng Liu, +6

Nature Biotechnology

Memory DeficitsSynaptic PlasticityGanglion CellDevelopmental BiologyDevelopmental Cognitive Neuroscience +10

Deficits in human trisomy 21 iPSCs and neurons

Jason P. Weick, Dustie L. Held, George F. Bonadurer, +13

Proceedings of the National Academy of Sciences

Down SyndromeCell LineageInduced Pluripotent Stem CellDevelopmental BiologyGenetic Disorder +12

iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration

Ruchira Singh, Wei Shen, David Kuai, +16

Human Molecular Genetics

Ocular DiseaseSubretinal FluidBd Hipsc-rpe RelativeRetinaAutophagy +14

High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial

Yuxuan Lin, Xiaoqing Zhang, Lizhi Li, +7

Gastrointestinal Endoscopy

GastroenterologyAnesthesia PracticeNon-operating Room AnesthesiaOxygen TherapyAnesthesia +3