Design, synthesis and biological evaluation of 7-(aryl)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline derivatives as potential Hsp90 inhibitors and anticancer agents

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

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Transcriptional Regulation, Signal Transduction, Cell Regulation +12

Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms

Lisa Wright, Xavier Barril, Brian Dymock et al. · Chemistry & Biology · 2004 · 265 citations · Full text

Hsp90 Isoforms, Signal Transduction, Biochemistry +5

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

Hardik Patel, Shanu Modi, Gabriela Chiosis et al. · Expert Opinion on Drug Discovery · 2011 · 100 citations

Synthesis and biological evaluation of quinoline analogues of flavones as potential anticancer agents and tubulin polymerization inhibitors

Nikta Shobeiri, Maryam Rashedi, Fatemeh Mosaffa et al. · European Journal of Medicinal Chemistry · 2016 · 97 citations

Medicinal Chemistry, Natural Product Synthesis, Biochemistry +10

Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazoles

Andreas Kreusch, Shulin Han, Achim Brinker et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 77 citations

Biochemistry, Natural Sciences, Protein X-ray Crystallography +3