Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Thomas Franke, Sung‐Il Yang, Tung O. Chan et al. · Cell · 1995 · 2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein

Subbiah Pugazhenthi, Albina Nesterova, Carol L. Sable et al. · Journal of Biological Chemistry · 2000 · 801 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis.

Stavroula Salakou, Dimitrios Kardamakis, Athanassios C. Tsamandas et al. · PubMed · 2007 · 310 citations

Life Sciences, Pathology, Apoptosis +15

Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation

Lige Song, Jiashen Zhao, Xiuzhen Zhang et al. · European Journal of Pharmacology · 2013 · 176 citations

Medicine, Biochemistry, Cell Biology +16

Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells

Byung-Hee Chung, Jong-Dai Kim, J. H. Kim et al. · Biochemical and Biophysical Research Communications · 2008 · 174 citations

Life Sciences, Cell Biology, Pharmacology +8