Neuron · 2016 · 185 citations · 53 references
Life SciencesNeurobiologyNeuroscienceExocytosisNeuroplasticitySynaptic PlasticityDendritic RemodelingDendritic Spine PlasticityDendritic StructureExtracellular MatrixLysosome BiologyStructural Synaptic PlasticityBackpropagating Action PotentialsCa2+ SignalingCathepsin ActivityDendritic SpinesLong-term Structural PlasticityLong-term Synaptic PlasticitySpine GrowthSpine Structural Plasticity
signaling or Cathepsin B release prevented the maintenance of dendritic spine growth induced by Hebbian activity. This impairment could be rescued by exogenous application of active MMP-9. Our findings suggest that activity-dependent exocytosis of Cathepsin B from lysosomes regulates the long-term structural plasticity of dendritic spines by triggering MMP-9 activation and ECM remodelling.
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NAADP mobilizes calcium from acidic organelles through two-pore channels
Peter Calcraft, Margarida Ruas, Zui Pan et al. · Nature · 2009 · 751 citations · Full text
Regulated ATP release from astrocytes through lysosome exocytosis
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