Concepedia

Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma

Ka Tat Siu, Janani Ramachandran, Andrew J. Yee, Homare Eda, Loredana Santo, Cristina Panaroni, Jennifer A. Mertz, Robert J. Sims, Michael R. Cooper, Noopur Raje

Leukemia · 2016 · 78 citations · 24 references

DOI

Concepts

References

24

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.2K citations

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang et al. · Nature · 2011 · 1.9K citations

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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Jan Krönke, Namrata D. Udeshi, Anupama Narla et al. · Science · 2013 · 1.8K citations · Full text

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Structure and ligand of a histone acetyltransferase bromodomain

Christophe Dhalluin, Justin E. Carlson, Lei Zeng et al. · Nature · 1999 · 1.7K citations

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