Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

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Life Sciences, Cell Biology, Molecular Biology +12

Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II

Fei Sun, Xia Huo, Yujia Zhai et al. · Cell · 2005 · 868 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency

Thomas Bourgeron, Pierre Rustin, Dominique Chrétien et al. · Nature Genetics · 1995 · 725 citations

Life Sciences, Genetics, Molecular Genetics +13

SDHA is a tumor suppressor gene causing paraganglioma

Nelly Burnichon, Jean-Jacques Brière, Rossella Libé et al. · Human Molecular Genetics · 2010 · 651 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Alfred Csibi, Sarah‐Maria Fendt, Chenggang Li et al. · Cell · 2013 · 585 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10