Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Dario R. Alessi, Ana Cuenda, Philip Cohen et al. · Journal of Biological Chemistry · 1995 · 3.4K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization

Jochen Schust, Bianca Sperl, Angela Hollis et al. · Chemistry & Biology · 2006 · 1.1K citations

Life Sciences, Medicinal Chemistry, Molecular Biology +11

Osteoarthritis development in novel experimental mouse models induced by knee joint instability

Satoru Kamekura, Kazuto Hoshi, Takashi Shimoaka et al. · Osteoarthritis and Cartilage · 2005 · 599 citations · Full text

Medicine, Orthopaedic Surgery, Orthopedic Surgery +16

Interleukin‐6 is a significant predictor of radiographic knee osteoarthritis: The Chingford study

Gregory Livshits, Guangju Zhai, Deborah Hart et al. · Arthritis & Rheumatism · 2009 · 380 citations · Full text

Medicine, Orthopaedic Surgery, Orthopedic Surgery +15

Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis

Pascal Richette, Christine Poitou, Patrick Garnero et al. · Annals of the Rheumatic Diseases · 2010 · 249 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17