Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

Norihiro Nishimoto, Kimio Terao, Toru Mima et al. · Blood · 2008 · 810 citations · Full text

Life Sciences, Immunology, Pharmacology +16

A microfabricated array bioreactor for perfused 3D liver culture

Mark J. Powers, Karel Domanský, Mohammad R. K. Mofrad et al. · Biotechnology and Bioengineering · 2002 · 464 citations

Engineering, Bioengineering, Biomedical Engineering +17

Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer

Edward T. Morgan, Kerry B. Goralski, Micheline Piquette‐Miller et al. · Drug Metabolism and Disposition · 2008 · 387 citations

Medicine, Pharmacokinetics, Pharmacology +16

Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family

Masahiko Mihara, Keiko Kasutani, Makoto Okazaki et al. · International Immunopharmacology · 2005 · 323 citations

Life Sciences, Immunology, Pharmacology +14

Multi-cell type human liver microtissues for hepatotoxicity testing

Simon Messner, Irina Agarkova, Wolfgang Moritz et al. · Archives of Toxicology · 2012 · 318 citations · Full text

Pharmacy, Pharmacology, Toxicology +16