Concepedia

Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors

Hiroshi Nara, Kenjiro Sato, Akira Kaieda, Hideyuki Oki, Haruhiko Kuno, Takashi Santou, Naoyuki Kanzaki, Jun Terauchi, Osamu Uchikawa, Masakuni Kori

Bioorganic & Medicinal Chemistry · 2016 · 32 citations · 40 references

DOIFull text

Open access

Concepts

References

40

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I

Charles G. Helmick, David T. Felson, Reva C. Lawrence et al. · Arthritis & Rheumatism · 2007 · 2.1K citations · Full text

, , +12

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

Peter G. Mitchell, Holly A. Magna, Lucy Reeves et al. · Journal of Clinical Investigation · 1996 · 943 citations · Full text

, , +15

Coxibs and Cardiovascular Disease

Garret A. FitzGerald · New England Journal of Medicine · 2004 · 896 citations

, , +15

Biochemical Characterization of Human Collagenase-3

Vera Knäuper, Carlos López-Otı́n, Bryan Ronain Smith et al. · Journal of Biological Chemistry · 1996 · 879 citations · Full text

, , +14

Activation of a recombinant membrane type 1‐matrix metalloproteinase (MT1‐MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)‐2

Hiroshi Sato, Takeshi Kinoshita, Takahisa Takino et al. · FEBS Letters · 1996 · 355 citations

, , +13