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Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines

Didier Meulendijks, Linda M. Henricks, André B. P. Kuilenburg, Bart Jacobs, Abidin Aliev, Lisette Rozeman, Judith Meijer, Jos H. Beijnen, Hiltje de Graaf, Annemieke Cats,

Cancer Chemotherapy and Pharmacology · 2016 · 24 citations · 16 references

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16

Comparison of Oral Capecitabine Versus Intravenous Fluorouracil Plus Leucovorin as First-Line Treatment in 605 Patients With Metastatic Colorectal Cancer: Results of a Randomized Phase III Study

Paulo M. Hoff, Rafat Ansari, Gerald Batist et al. · Journal of Clinical Oncology · 2001 · 1.1K citations

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Superior Survival With Capecitabine Plus Docetaxel Combination Therapy in Anthracycline-Pretreated Patients With Advanced Breast Cancer: Phase III Trial Results

Joyce O’Shaughnessy, David Miles, Svetislava J. Vukelja et al. · Journal of Clinical Oncology · 2002 · 1.1K citations

, , +14

Upfront Genotyping of <i>DPYD</i>*<i>2A</i> to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis

Maarten J. Deenen, Didier Meulendijks, Annemieke Cats et al. · Journal of Clinical Oncology · 2015 · 345 citations · Full text

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Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

Kelly E. Caudle, Caroline F. Thorn, Teri E. Klein et al. · Clinical Pharmacology & Therapeutics · 2013 · 322 citations · Full text

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Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.

André B. P. Kuilenburg, E.W. Muller, Janet Haasjes et al. · PubMed · 2001 · 255 citations

, , +17