Adipogenesis, lipogenesis and lipolysis is stimulated by mild but not severe hypoxia in 3T3-L1 cells

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with oil red O

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

David R. Wise, Patrick S. Ward, Jessica E.S. Shay et al. · Proceedings of the National Academy of Sciences · 2011 · 968 citations

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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of<i>ob</i>/<i>ob</i>and dietary obese mice

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