Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats - Concepedia

Concepedia

Publication | Open Access

Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats

DOI Full Paper Access

200

Citations

23

References

2016

Year

Mingming Zhang, Qian Zhou, Robert Dorfman, Xiaoli Huang, Tingting Fan, Hao Zhang, Jun Zhang, Chenggong Yu

BMC Gastroenterology

Abstract

Our results suggest that butyrate plays a key role in regulating the Treg/Th17 balance and ultimately protects the colon mucosa against the development of IBD.

References

	Year	Citations
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Estelle Bettelli, Yijun Carrier, Wenda Gao, Nature Developmental BiologyAutoimmune DiseaseLymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune System	2006	6.8K
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Nature InflammationMucosal ImmunologyCommensal Microbe-derived ButyrateT-regulatory CellImmunology	2013	5.1K
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Nicholas Arpaia, Clarissa Campbell, Xiying Fan, Nature Microbial PathogensT-regulatory CellPathogenesisImmunologyBacteriology	2013	4.5K
<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients Harry Sokol, Bénédicte Pigneur, Laurie Watterlot, Proceedings of the National Academy of Sciences DysbiosisImmunologyGastroenterologyBacterial PathogensAnti-inflammatory Commensal Bacterium	2008	4.2K
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. Kensuke Inaba, Muneo Inaba, Nikolaus Romani, The Journal of Experimental Medicine	1992	3.7K
Transforming growth factor-β induces development of the TH17 lineage Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn, Nature Developmental BiologyTh17 LineageCell ProliferationCell GrowthGene Expression	2006	3K
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis Aurélien Trompette, Eva S. Gollwitzer, Koshika Yadava, Nature Medicine AsthmaNutritionMicrobiota FunctionDysbiosisAllergy	2014	2.7K
A decrease of the butyrate-producing species <i>Roseburia hominis</i> and <i>Faecalibacterium prausnitzii</i> defines dysbiosis in patients with ulcerative colitis Kathleen Machiels, Marie Joossens, João Sabino, Gut	2013	1.8K
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor Erik‐Oliver Glocker, Daniel Kotlarz, Kaan Boztuǧ, New England Journal of Medicine	2009	1.4K
Antibodies to interleukin 12 abrogate established experimental colitis in mice. MF Neurath, Ivan J. Fuss, Brian L. Kelsall, The Journal of Experimental Medicine Chronic Inflammatory DiseasesImmunologyGastroenterologyPathologyRectal Prolapse	1995	1.3K

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