Concepedia

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

Wei‐Wei Luo, Shu Li, Chen Li, Huan Lian, Qing Yang, Bo Zhong, Hong‐Bing Shu

Nature Immunology · 2016 · 245 citations · 29 references

DOI

Concepts

References

29

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.8K citations

, , +16

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa, Glen N. Barber · Nature · 2008 · 3.5K citations · Full text

, , +12

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa, Zhe Ma, Glen N. Barber · Nature · 2009 · 2.7K citations · Full text

, , +14

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Jiaxi Wu, Lijun Sun, Xiang Chen et al. · Science · 2012 · 2.5K citations

, , +17

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Akinori Takaoka, Zhichao Wang, Myoung Kwon Choi et al. · Nature · 2007 · 1.7K citations

, , +14