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Influence of the CYP3A4/5 genetic score and ABCB1 polymorphisms on tacrolimus exposure and renal function in Brazilian kidney transplant patients

Fabiana Dalla Vecchia Genvigir, Patricia C. Salgado, Cláudia Rosso Felipe, Elena Y.F. Luo, Camila Fernanda da Silveira Alves, Álvaro Cerda, Hélio Tedesco‐Silva, José Osmar Medina Pestana, N. Oliveira, Alice Cristina Rodrigues,

Pharmacogenetics and Genomics · 2016 · 37 citations · 34 references

DOIFull text

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Abstract

The results show the impact of the CYP3A4/5 genetic score on TAC exposure and renal function in Brazilian patients. Furthermore, ABCB1 polymorphisms, in a combined analysis, influenced TAC Co/D at 30 days after transplantation.

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