Concepedia

Tacrolimus Exposure

Tacrolimus Exposure is a pharmacokinetic construct that quantifies the cumulative systemic availability of tacrolimus, an immunosuppressive agent, over time, typically measured through area under the concentration-time curve, to assess the extent of drug delivery influencing immunosuppression and risk of nephrotoxicity in recipients of allogeneic renal transplants.

1.2K

Publications

49.1K

Citations

6.5K

Authors

1.5K

Institutions

Publications per year

2017–2026

251

Parents

Publications

1.2K

Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients

Olwyn Johnston, Caren Rose, Angela C Webster et al. · Journal of the American Society of Nephrology · 2008 · 424 citations

, , +15

Comparison of the Effects of Tacrolimus and Cyclosporine on the Pharmacokinetics of Mycophenolic Acid

Teun van Gelder, J Klupp, M.J. Barten et al. · Therapeutic Drug Monitoring · 2001 · 334 citations

, , +17

Everolimus With Reduced Tacrolimus Improves Renal Function in De Novo Liver Transplant Recipients: A Randomized Controlled Trial

Paolo De Simone, Frank Nevens, Luciano De Carlis et al. · American Journal of Transplantation · 2012 · 329 citations · Full text

, , +17

A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus11This study was sponsored by a grant from Fujisawa USA, Deerfield, Illinois.22The authors were working on behalf of the Tacrolimus US Heart Transplant Multicenter Study Group. Other members of the Study Group included (principal investigator listed first): UTAH Cardiac Transplant Program, Salt Lake City, Utah: David O. Taylor, MD, Dale G. Renlund, MD, Abdallah G. Kfoury, MD; St. Luke’s Episcopal Hospital/Texas Heart Institute, Houston, Texas: O. H. Frazier, MD, Branislav Radovancevic, MD, Edward K. Massin, MD; University of Wisconsin Hospitals and Clinics, Madison, Wisconsin: Robert M. Mentzer, Jr., MD, Charles C. Canver, MD, Robert B. Love, MD; Ochsner Medical Foundation, New Orleans, Louisiana: Frank W. Smart, MD, Hector O. Ventura, MD, Dwight D. Stapleton, MD, Mandeep Mehra, MD; University of Southern California, Los Angeles, California: Mark L. Barr, MD, Vaugh A. Starnes, MD; Medical College of Virginia, Richmond, Virginia: David E. Tolman, MD, Albert Guerraty, MD, David Salter, MD; Cleveland Clinic Foundation, Cleveland, Ohio: James B. Young, MD; Data Management and Statistical Coordinating Center-The EMMES Corporation, Potomac, Maryland: Paul VanVeldhuisen, MS, Anne Lindblad, PhD, Anita Yaffe, MSN, MPH.

David O. Taylor, Mark L. Barr, Branislav Radovančević et al. · The Journal of Heart and Lung Transplantation · 1999 · 320 citations

, , +16

Impact of cytochrome P450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients1 2

Éric Thervet, Dany Anglicheau, Barry P. King et al. · Transplantation · 2003 · 300 citations

, , +17

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Authors

6.5K

  1. DK
    Dirk Kuypers

    KU Leuven, Belgium

    31 publications · 2.1K citations

    23

    h-index

  2. TV
    Teun van Gelder

    Erasmus MC, Netherlands

    27 publications · 1.7K citations

    20

    h-index

  3. PM
    Pierre Marquet

    Université de Limoges, France

    19 publications · 944 citations

    16

    h-index

  4. DA
    Dennis A. Hesselink

    Erasmus MC, Netherlands

    21 publications · 1.1K citations

    15

    h-index

  5. HT
    Hélio Tedesco‐Silva

    Hospital do Rim e Hipertensão, Brazil

    15 publications · 867 citations

    14

    h-index

1–5 of 6.5K

Institutions

1.5K

  1. KU Leuven

    Leuven, Belgium

    29 h-index

    164 publications

    10.2K citations

  2. Inserm

    Paris, France

    21 h-index

    145 publications

    7.4K citations

  3. University of Pittsburgh

    Pittsburgh, United States

    21 h-index

    143 publications

    9.2K citations

  4. Erasmus MC

    Rotterdam, The Netherlands

    21 h-index

    147 publications

    6.9K citations

  5. Medizinische Hochschule Hannover

    Hanover, Germany

    19 h-index

    88 publications

    3.9K citations

  6. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    18 h-index

    72 publications

    2.5K citations

  7. Heidelberg University

    Heidelberg, Germany

    18 h-index

    50 publications

    2.6K citations

  8. Leiden University Medical Center

    Leiden, The Netherlands

    17 h-index

    55 publications

    3.5K citations

1–8 of 1.5K

Venues

  1. Transplantation

    104 publications · 6.8K citations

    46

    h-index

  2. American Journal of Transplantation

    52 publications · 4.1K citations

    37

    h-index

  3. Transplantation Proceedings

    128 publications · 3.2K citations

    30

    h-index

  4. PubMed

    Repository · 57 publications · 2.1K citations

    27

    h-index

  5. Transplant International

    38 publications · 1.6K citations

    24

    h-index

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