Concepedia

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines

Ιoannis V. Pavlidis, Martin S. Weiß, Maika Genz, Paul Spurr, Steven P. Hanlon, Beat Wirz, Hans Iding, Uwe T. Bornscheuer

Nature Chemistry · 2016 · 241 citations · 26 references

DOI

Concepts

References

26

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff et al. · Science · 2010 · 1.7K citations

, , +16

Rational assignment of key motifs for function guides in silico enzyme identification

Matthias Höhne, Sebastian Schätzle, Helge Jochens et al. · Nature Chemical Biology · 2010 · 369 citations

, , +17

Modeling of the spatial structure of eukaryotic ornithine decarboxylases

Nick V. Grishin, Margaret A. Phillips, Elizabeth J. Goldsmith · Protein Science · 1995 · 340 citations · Full text

, , +17

The M5nr: a novel non-redundant database containing protein sequences and annotations from multiple sources and associated tools

Andreas Wilke, Travis Harrison, Jared Wilkening et al. · BMC Bioinformatics · 2012 · 331 citations · Full text

, , +17

Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis

Ursula Kaulmann, Kirsty Smithies, Mark E. B. Smith et al. · Enzyme and Microbial Technology · 2007 · 309 citations

, , +14