Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines

Ιoannis V. Pavlidis, Martin S. Weiß, Maika Genz, +5

Nature Chemistry

Asymmetric CatalysisEngineeringAsymmetric SynthesisOrganic ChemistryStereoselective Synthesis +5

"Pagodane": the efficient synthesis of a novel, versatile molecular framework

Wolf Dieter Fessner, Gottfried Sedelmeier, Paul Spurr, +2

Journal of the American Chemical Society

Combinatorial ChemistryEngineeringChemical AnalysisAltmetric Attention ScoreOrganic Chemistry +16

New, Efficient Synthesis of Oseltamivir Phosphate (Tamiflu) via Enzymatic Desymmetrization of a <i>meso</i>-1,3-Cyclohexanedicarboxylic Acid Diester

Ulrich Zutter, Hans Iding, Paul Spurr, +1

The Journal of Organic Chemistry

Pig Liver EsteraseOseltamivir Phosphate 1Efficient SynthesisEnzymatic DesymmetrizationChemical Biology +16

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1<i>H</i>-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

Georg Jaeschke, Sabine Kolczewski, Will Spooren, +31

Journal of Medicinal Chemistry

Psychotropic MedicationPsychopharmacologyPharmacotherapyPsychiatric DiseasesPharmaceutical Chemistry +17

Amine Transaminase Engineering for Spatially Bulky Substrate Acceptance

Martin S. Weiß, Ιoannis V. Pavlidis, Paul Spurr, +4

ChemBioChem

Amine TransaminaseEngineeringMolecular BiologyOrganic ChemistryBiomimetic Chemistry +14

Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine

Martin S. Weiß, Ιoannis V. Pavlidis, Paul Spurr, +4

Organic & Biomolecular Chemistry

The Pagodane Route to Dodecahedranes Unsaturated (Hyperstable) and Saturated Bissecododecahedranes

Bulusu A. R. C. Murty, Rolf Pinkos, Paul Spurr, +5

Chemische Berichte

Membrane StructureChemical EngineeringLow Oxidation PotentialsEngineeringMembrane Formation +10

[6+6]-benzo/benzo - photocycloaddition reactions

Gottfried Sedelmeier, H.-D. Fessner, C. Grund, +3

Tetrahedron Letters

Photocycloaddition ReactionsChemical EngineeringEngineeringPhotoredox ProcessPhotochemistry +3

Bissecododecahedraenes, Unusual Hyperstable Olefins

Paul Spurr, Bulusu A. R. C. Murty, Wolf‐Dieter Fessner, +2

Angewandte Chemie International Edition in English

Crystal StructureChemical EngineeringBissecododecahedradienes 3EngineeringIdeal Colinear Orientation +6

Reductive Elimination of Bromine from 2,3-Disubstituted 1,4-Dibromo-2-butenes by Iodide Ion: A Convenient Route to 2,3-Bis[iodomethyl]-1,3-butadiene and Related Compounds

D. P. G. HAMON, Paul Spurr

Synthesis

Chemical Engineering2,3-Disubstituted 1,4-Dibromo-2-butenesEngineeringOrganic ChemistryReductive Elimination +5