Concepedia

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

V. Martínez-Cisuelo, José Gómez, I. García-Junceda, Alba Naudí, Rosanna Cabré, Natàlia Mota‐Martorell, Mónica Lopez‐Torres, M. González-Sánchez, Reinald Pamplona, Gustavo Barja

Experimental Gerontology · 2016 · 114 citations · 30 references

DOI

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References

30

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Nao Hosokawa, Taichi Hara, Takeshi Kaizuka et al. · Molecular Biology of the Cell · 2009 · 2K citations · Full text

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Andreas Bender, Kim J. Krishnan, Christopher M. Morris et al. · Nature Genetics · 2006 · 1.6K citations

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mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

John T. Cunningham, Joseph T. Rodgers, Daniel H. Arlow et al. · Nature · 2007 · 1.5K citations

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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Richard A. Miller, Clinton M. Astle, Joseph A. Baur et al. · The Journals of Gerontology Series A · 2010 · 913 citations · Full text

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