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Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

MitophagyMtdna FragmentsMitochondrial FunctionLongevityGeneticsAutophagyNuclear DnaMetabolismMedicineCell BiologyOxidative Stress