Antioxidative therapy in an ex vivo human cartilage trauma-model: attenuation of trauma-induced cell loss and ECM-destructive enzymes by N-acetyl cysteine

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.

Ralf Schreck, P. Rieber, Patrick A. Baeuerle · The EMBO Journal · 1991 · 3.8K citations · Full text

Life Sciences, Immunology, Molecular Biology +11

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

Okezie I. Aruoma, Barry Halliwell, Brigid M. Hoey et al. · Free Radical Biology and Medicine · 1989 · 1.8K citations

Life Sciences, Biochemistry, Pharmacology +14

The epidemiology and impact of pain in osteoarthritis

Tuhina Neogi · Osteoarthritis and Cartilage · 2013 · 1.7K citations · Full text

Medicine, Orthopaedic Surgery, Orthopedic Surgery +10

Reactive Oxygen Species, Aging, and Antioxidative Nutraceuticals

J. Lee, Nayeon Koo, David B. Min · Comprehensive Reviews in Food Science and Food Safety · 2004 · 854 citations

Life Sciences, Nutrition, Nutritional Sciences +17

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

Yvonne Lo, Johnson M. S. Wong, Tony F. Cruz · Journal of Biological Chemistry · 1996 · 498 citations · Full text

Life Sciences, Cell Biology, Cell Signaling +16