Journal of Developmental Biology · 2016 · 17 citations · 42 references
Life SciencesDevelopmental BiologyImmunologyCell DifferentiationCell Fate SpecificationEmbryogenesisHedgehog SignalingImmune Cell DifferentiationT Cell BiologyT Cell DevelopmentT Cell DifferentiationThymic DevelopmentHedgehog Signaling In DifferentiationMultipotent Progenitor CellsProgenitor CellsT Cell Fate SpecificationT Cell Progenitor DifferentiationThymic Epithelial Cell DifferentiationThymic Epithelial Progenitor CellsThymic T Cell Development
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.
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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chin Chiang, Ying Litingtung, Eric Lee et al. · Nature · 1996 · 3.1K citations