Concepedia

Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

L. Petersen, Peter Blakskjær, A. Chaikuad, Allan Beck Christensen, Judith Dietvorst, Johan Holmkvist, Stefan Knapp, Marek Kořínek, Lesley Larsen, Anna-Kathrine Pedersen,

MedChemComm · 2016 · 84 citations · 24 references

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Concepts

Abstract

A DNA-encoded small-molecule library was prepared using yoctoReactor technology followed by binder trap enrichment to identify selective inhibitors with nanomolar potencies against p38α MAP kinase.

References

24

Features and development of <i>Coot</i>

Paul Emsley, Bernhard Lohkamp, W. G. Scott et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 29.6K citations · Full text

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<i>Phaser</i>crystallographic software

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<i>REFMAC</i>5 for the refinement of macromolecular crystal structures

Garib N. Murshudov, Pavol Skubák, Andrey A. Lebedev et al. · Acta Crystallographica Section D Biological Crystallography · 2011 · 8.7K citations · Full text

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Scaling and assessment of data quality

Acta Crystallographica Section D Biological Crystallography · 2005 · 4.5K citations · Full text

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<i>iMOSFLM</i>: a new graphical interface for diffraction-image processing with<i>MOSFLM</i>

T. Geoff G. Battye, Luke Kontogiannis, Owen Johnson et al. · Acta Crystallographica Section D Biological Crystallography · 2011 · 2.9K citations · Full text

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